ACTIVATION OF HUMAN AND MOUSE 2-5A SYNTHETASES AND MOUSE PROTEIN P, KINASE BY NUCLEIC ACIDS Structure-activity relationships and correlations with inhibition of protein synthesis and interferon induction

The natural occurrence of fully double-stranded RNA (dsRNA) of high molecular weight in viruses, virus-like particles in fungi, as intermediates in the replication of RNA and DNA viruses has suggested some possible biological role for such molecules [ 11. Interest in dsRNA as a possible regulatory signal has been generated by the observations that dsRNA is a potent interferon inducer [2] and a powerful inhibitor